They'll do that with victory over Manchester United at Old Trafford in the lunchtime kick-off.
With Zlatan Ibrahimovic suspended, Marcus Rashford gets his chance up front for United.
Anthony Martial gets his first start for United since September while Antonio Valencia also returns after having surgery on a broken arm.
Michael Carrick captains today, while Wayne Rooney is on the bench.
Carl Jenkinson comes in at right-back to make his first league start for Arsenal in two-and-a-half years!
Mohamed Elneny also starts while Aaron Ramsey make his first Premier League start since the opening day of the season
The action in Manchester gets underway at 12.30pm.
At three, Liverpool will look to strengthen their lead at the top of the table with victory at Southampton.
If they slip up, Manchester City can return to the summit with a win at Crystal Palace.
Elsewhere, bottom of the table Sunderland welcome Hull, champions Leicester head to Watford, Everton entertain Swansea and Stoke face Bouremouth.
Fifth placed Tottenham host London rivals West Ham in the late game at 5.30pm.
