Three of those changes are seen in the pack with Dave Kilcoyne and Mike Sherry returning to the front row alongside John Ryan who remains at tighthead.
Dave O'Callaghan makes his first start since returning from an adductor injury at openside.
Billy Holland remains as captain and blindside flanker with Jack O'Donoghue making the positional switch to number 8 for the first time this season.
The only change across the backline comes at scrum half with Duncan Williams returning to partner Ian Keatley in the half-backs.
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Clonmel's Dave Foley is also in the starting XV for the game against the Welsh side.
