Tipperary's Dave Foley and Tommy O' Donnell start for Munster at the Aviva, with captain Peter O' Mahony named on the bench.
Stephen Archer and James Cronin join Duncan Casey in the front row, while Andrew Smith comes into the side partnering Denis Hurley in the centre.
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And there are three changes to the Leinster pack, with Jack McGrath, Mike Ross and Mike McCarthy all set to start.
Both teams have made indifferent starts to the league season, each with two wins and two losses.
Despite the profile of the game, Munster head coach Anthony Foley says clear heads must be the order of the day.
Kick-off at the Aviva Stadium is at 6:30.
