In the opening game of the day, Bradford are the lowest-ranked side remaining in the Cup as they prepare to host Reading at Valley Parade.
The League One club have beaten Chelsea and Sunderland on their run-up to today's 12:45 start.
Later this evening, Aston Villa and West Brom will meet for the second time this week.
After Villa got the better of their midlands rivals during Tuesday's league meeting, West Brom return to Villa Park this evening looking for revenge.
Villa boss Tim Sherwood has warned his players that they're going to have to work hard if they want to advance to a semi-final date at Wembley.
Kick-off is at half-past five.
Because of the FA Cup fixtures, there's just one game this weekend in the Barclays Premier League.
QPR will play host to London rivals Tottenham at three o'clock.
