Manchester City and Arsenal meet at the Etihad Stadium at 4.00pm.
City have won just four of their last 10 league matches while Arsenal were defeated by Everton on Wednesday, which ended an unbeaten league run that stretched back to the opening day.
City manager Pep Guardiola knows it won't be easy against Arsene Wenger's attacking side.
Elsewhere at 4.00pm, Tottenham will be looking to maintain their good form at White Hart Lane with the visit of Burnley.
Spurs are unbeaten at home in the League this season.
Meanwhile, Burnley have the worst away record in the league with just one point taken from their seven away days.
First up at 1.30pm, Bournemouth will be hoping to record back-to-back wins for the first time since March against south coast rivals Southampton.
Southampton have only won five of their 16 league matches this season.
