The draw, which took place on Sunday evening, has pitted the defending champions Loughmore-Castleiney against senior newcomers Ballina.
North champions Nenagh Éire Óg face Kilruane MacDonaghs.
Mid winners Drom & Inch will meet their divisional rivals Thurles Sarsfields.
Kildangan will play Lorrha.
Moycarkey-Borris will take on Templederry Kenyons.
And Borris-Ileigh will take on Burgess.
The biggest news is that there will be a repeat of both the West and South Senior hurling finals.
West title holders Éire Óg Anacarty's reward for retaining their title against Clonoulty-Rossmore yesterday is a tie against the same opposition, while Mullinahone will have to beat Killenaule, which they managed to do on Sunday as they went on to become South champions.
