Corner-back Damien Cahalane gets his first senior start of the season as Jimmy Barry Murphy has named a new-look full-back line.
Cahalane is joined by Killian Burke and Eoin Keane with Kilian Murphy and Shane O'Neill both out injured, while Stephen McDonnell is unavailable due to work commitments.
Eamon O’Shea will name the Tipp team on Saturday afternoon.
You can hear all the action on Tipp FM, when we bring you live coverage of the last eight meeting in association with Philly's Bar, Nenagh.
Throw-in in Thurles on Sunday is at 3:45, with our build-up getting underway from 3:15.
Tipp FM will also bring you live updates from this Sunday's Allianz Football League Division 4 meeting between Leitrim and Tipperary.
That game at Pairc Sean Mac Diarmada will throw-in at 2 o'clock.
