Pat Lam's side take on the high-flying Welsh men at Swansea's Liberty Stadium at 1.30pm.
A win for the Ospreys would see them leapfrog Munster at the summit.
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Glasgow host the Cardiff Blues at 7.35pm.
Last night joint leaders Leinster ran in 10 tries in a 70-6 win over Zebre at the RDS.
Rory O'Loughlin got a hat-trick.
Ulster returned home with a losing bonus point after being edged out 16-13 at the Scarlets.
