The Gunners need to defeat Olympiakos by two clear goals if they're to clinch a remarkable turn-around and progress as group runners-up behind Bayern Munich.
Meanwhile, Chelsea need at least a point from their meeting with Porto at Stamford Bridge in order to secure a place in the last-16.
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The Blues need a result from tonight's clash in order to ease some of the pressure on under fire manager Jose Mourinho.
Kick-off in all of tonight's games is at 7.45.