The event, one of the biggest in the horse racing calendar, will take place on the 31st of October and the first of November at Santa Anita Park in Los Angeles.
O'Brien has a strong tradition in the Breeders Cup, producing 4 winners in the past.
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The Ballydoyle trainer says he is hopeful some of his top runners will travel including The Great War, Magician and War Envoy.
