Arsenal need a win to keep their title challenge alive but they're making the trip to the Boylen Ground to challenge a West Ham side that are desperate to hold onto their spot in the top-six.
Gunners boss Arsene Wenger knows that a win would get his side to within eight points of league leaders Leicester – but he's also wary of what a defeat would mean to his team…
– Kick-off at Upton Park is at 12:45 today.
The relegation battle is on the agenda for the mid-afternoon matches in the top-flight.
Bournemouth can get past the 40-point barrier with a win over basement side Aston Villa
Second-from-bottom Newcastle are in dire need of a win as they travel to Southampton while Norwich and Crystal Palace occupy the two spots immediately above the drop-zone ahead of their clash at Selhurst Park.
In today's other three o'clock games, Chelsea travel to face Swansea while Watford host Everton.
– The late game today in the top-flight will see West Brom hoping to take advantage of Man City's European involvement mid-week as the Baggies make the trip to the Ethiad Stadium for a half-five start.
Burnley get a chance to put some daylight between themselves and the other promotion hopefuls when they host Leeds in the early game in the Championship.
Kick-off at Turf Moor is at 12:30.
Second-placed Middlesbrough will be at home to Preston later this afternoon.
Celtic have a chance to open-up an eight-point lead at the top of the table in the early kick-off today in the Scottish Premiership.
After Aberdeen slipped-up last night, the Hoops can take another significant step towards the title when they visit Motherwell in a 12:30 start.
There's also two games tonight in the Airtricity League Premier Division.
After Derry's win over Shamrock Rovers last night, defending champions Dundalk can regain the top-spot tonight with a win over their hosts Longford Town.
And Bray Wanderers will host Bohemians at the Carlisle Grounds.
Both games will kick-off at half-past seven.