With leaders Dundalk not in action, second-placed Derry City and third-placed Shamrock Rovers both have a chance to move to the top of the table as they go head-to-head at the Brandywell.
Cork City will be expected to beat new-comers the Wexford Youths at Turners Cross.
Elsewhere, Galway United host Finn Harps and Sligo Rovers travel to face St. Pat's.
In the First Division, early pace-setters Limerick FC are away to fellow promotion contenders Drogheda United.
Elsewhere, Athlone Town host Waterford United, Cobh Ramblers go to Cabinteely and Shelbourne hoist UCD at Tolka Park.
In the Scottish Premiership tonight, Aberdeen have a chance to move to within two points of Celtic at the top of the table.
The Dons travel to face Hearts tonight in the only game in the SPL.
Kick-off in all of those games tonight is at 7:45.
