A young child was among those injured in the multi-vehicle crash in the village of Holycross last evening.
Four people were hospitalised following the collision which happened around 6.45pm on the R660 Holycross to Thurles road.
A three year old child suffered serious but not life threatening injuries in the three-car crash which led to the road being closed overnight and this morning.
It has since reopened following an examination of the scene by Garda Forensic Collision Investigators.
A man was arrested following the collision and detained by Gardaí.