The single vehicle crash occurred just after 8.30 this morning on the Bansha Road outside Cahir.
A car heading towards Cahir left the N24 just a few hundred metres from the Tipperary Road Roundabout.
The sole occupant of the vehicle – a 19 year old female – suffered fatal injuries in the collision.
Gardaí in Cahir are advising motorists to avoid the area – diversions are in place via Cashel
The N24 Cahir – Tipperary road is expected to remain closed until at least 2pm.
This is the first fatal crash in Tipperary this year – a total of 11 people died on the roads of the Premier County last year.
