It's understood up to a dozen vehicles were involved in the collision on the main Dublin – Limerick road during heavy hail and sleet last night.
The man in his 50s was pronounced dead at the scene and his body was taken to University Hospital Limerick where a post mortem will take place.
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The southbound lane was closed for a time to allow a forensic examination of the scene – it has now reopened to traffic.
Anyone who witnessed the incident is asked to contact Nenagh Gardaí.
This is the second road fatality in the Premier County this year – an 87 year old woman died in a single vehicle crash near Nenagh on New Years Day.
