A severe lack of funds means the group have had to implement cost cutting measures including the closure of the Nenagh and Ennis service for at least a month.
Limerick meanwhile will only provide a limited service over the coming months.
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A number of staff are taking unpaid leave in a bid to ease the financial pressure on the centres.
Executive director of the mid-west Rape Crisis Centre Miriam Duffy says despite all their efforts they are still facing into major financial problems with a shortfall of around €40,000.