Gardai were called to scene in the North Tipp town in the early hours of this morning.
The alarm was raised around 2.30 this morning at a house in The Maltings, Roscrea.
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When Gardai arrived they discovered a man in his early 40s with stab wounds – he was pronounced dead at the scene.
A short time later, a woman in her mid-40s was arrested.
She's currently being held at Nenagh Garda Station under section 4 of the Criminal Justice Act.
The victim's body is still at the scene this afternoon.
The State Pathologist has been notified and the scene has been sealed off.