Among those who have travelled to Italy for the gathering – are members of the families affected by the Carrickmines fire tragedy.
Thousands of people are expected to attend the service – to mark the 50th anniversary of the first ever visit by a pontiff to a gypsy camp – in 1965.
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Last week Pope Francis sent a letter of condolence to read at the funerals of the 10 fire victims in Bray and Dublin.