The single vehicle crash happened on the M7 motorway near Nenagh.
The driver was the only occupant of the car – she was pronounced dead at the scene.
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It’s understood the vehicle struck a barrier on the northbound lane just after Junction 24 at around 7am.
The motorway will be closed for a number of hours while Gardaí conduct a forensic collision investigation at the scene.
Diversions are in place between Junction 24 Toomevara and Junction 23 Moneygall
Anyone who may have witnessed the crash is asked to contact Gardai in Nenagh on 067 50450, the Garda confidential line on 1800 666 111 or any Garda station.
This morning’s fatality brings to 8 the number of people killed on the roads of Tipperary in 2017.
