An planning application was lodged last July relating to the former Town Council offices at Stradavoher on the Slievenamon Road in Thurles.
Paul Ryan and David Millman proposed a change of use for the property to accommodate a medical centre.
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The works include the provision of consultant rooms, treatment rooms and offices.
The building is a protected structure.
The developers also sought permission to erect a new boundary wall and entrance gates.
Further information was sought from Tipperary County Council in early September with conditional approval granted in recent days.