123 people in South Tipperary received opioid-substitution treatment in the first half of this year.
The numbers in the North Tipp/East Limerick area amounted to 66.
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In Ireland, the main treatment for opioid addiction involves methadone and the drug buprenorphine.
According to information released under the Freedom of Information Act 7,645 people across the country received opioid-substitution prescriptions from a community pharmacy in the first six months of this year.
More than half of the addicts were in Dublin, while Cork and Limerick were the next highest.