Robbie Diack is the only new cap in the starting XV, with the Ulsterman set to wear the No.6 jersey.
There are two further uncapped players on the bench as Connacht dup Kieran Marmion and Rodney Ah You hope to claim their first cap.
The front row sees Jack McGrath win his 9th cap alongside Rory Best and Mike Ross.
Captain Paul O'Connell is partnered in the second row by Iain Henderson.
The back-row consists of Ulster team-mates Diack and Chris Henry with Leinster's Jordi Murphy at No.8.
Conor Murray and Jonathan Sexton start at half-back with Luke Marshall and Darren Cave in the centre.
The back three is made up of Simon Zebo, Andrew Trimble with Felix Jones at full-back.
Ireland will play Argentina in the first of two Tests at the Estadio Centenario, Resistencia, Chaco.
The game will kick-off at 3:40 local time (7:40 Irish time)
15. Felix Jones (Shannon/Munster) 5
14. Andrew Trimble (Ballymena/Ulster) 55
13. Darren Cave (Belfast Harlequins/Ulster) 5
12. Luke Marshall (Ballnyahinch/Ulster) 5
11. Simon Zebo (Cork Constitution/Munster) 6
10. Jonathan Sexton (Racing Metro 92) 43
9. Conor Murray (Garryowen/Munster) 27
1. Jack McGrath (St. Mary's College/Leinster) 8
2. Rory Best (Banbridge/Ulster) 75
3. Mike Ross (Clontarf/Leinster) 39
4. Iain Henderson (Ballynahinch/Ulster) 10
5. Paul O'Connell (Young Munster/Munster) 92 capt
6. Robbie Diack (Malone/Ulster) *
7. Chris Henry (Malone/Ulster) 14
8. Jordi Murphy (Lansdowne/Leinster) 2
Replacements
16. Damien Varley (Garryowen/Munster) 2
17. Dave Kilcoyne (UL Bohemians/Munster) 8
18. Rodney Ah You (Buccaneers/Connacht) *
19. Devin Toner (Lansdowne/Leinster) 15
20. Jamie Heaslip (Dublin University/Leinster) 65
21. Kieran Marmion (Corinthians/Connacht) *
22. Ian Madigan (Blackrock/Leinster) 8
23. Fergus McFadden (Old Belvedere/Leinster) 26
