Kick-off in Cork is at 7:15, with winger Gerhard van den Heever making his home debut, while hooker Duncan Casey makes his competitive debut for the province.
They're two of 12 changes made by coach Rob Penney. Elsewhere Connacht will take on the Dragons at the Sportsground at 5.
Meanwhile; Ulster closed the gap with Munster to two points as they defeated Zebre by 13-6 at Ravenhill last night.
However, a disappointing Leinster slipped to third, after they lost by 11-6 against Edinburgh at Murrayfield.
