Simon Zebo will start at full-back with Trimble and Earls on the wings and Payne and Henshaw in the centre.
Sexton and Murray are likely to pair up in the half-backs.
McGrath, Best and White form the front row with Toner and McCarthy in the second row.
In the back row CJ Stander makes his debut with Cahir man Tommy O'Donnell at openside and Jamie Heaslip at number 8.
Nenagh's Donnacha Ryan is on the bench alongside Sean Cronin, James Cronin, Tadhg Furlong, Rhys Ruddock, Kieran Marmion, Ian Madigan and Dave Kearney.
